Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Mar;13(3):407-16.

Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia

J C Cawley, C R Barker, R D Britchford, J L Smith

Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia

J C Cawley et al. Clin Exp Immunol. 1973 Mar.

Abstract

Lymphocytes from a case of chronic lymphocytic leukaemia were found to contain crystalline protein inclusions within cisternae of rough endoplasmic reticulum. These inclusions were characterized as IgA λ immunoglobulin and differed from the immunoglobulins found at the surface of the cells containing the inclusions. No serum paraprotein was detected in the serum of the patient, although small amounts of λ light chain protein were present in the urine. These observations suggest that the crystalline immunoglobulin was not excreted in significant amounts by the lymphocytes.

PubMed Disclaimer

References

    1. Aust J Exp Biol Med Sci. 1967 Dec;45(6):629-43 - PubMed
    1. J Immunol. 1969 Jun;102(6):1388-93 - PubMed
    1. Lancet. 1971 Oct 16;2(7729):850-2 - PubMed
    1. Ann N Y Acad Sci. 1971 Dec 31;190:250-67 - PubMed
    1. Ann N Y Acad Sci. 1971 Dec 31;190:420-31 - PubMed

MeSH terms

LinkOut - more resources