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. 1979 Jan;42(1):41-50.
doi: 10.1679/aohc1950.42.41.

Electron microscopic study of macrophages appearing in a stab wound of the brain of rats following intravenous injection of carbon particles

E A Ling

Electron microscopic study of macrophages appearing in a stab wound of the brain of rats following intravenous injection of carbon particles

E A Ling. Arch Histol Jpn. 1979 Jan.

Abstract

Colloidal carbon was introduced intravenously into young rats to label circulating monocytes before the stabbing of the brain. The rats were sacrificed 1 to 14 days after the stab wound. In the rats sacrificed between 3 to 7 days after the stabbing, numerous phagocytic cells were present in the needle wound. Electron microscope study showed that some of these phagocytic cells carried intracytoplasmic carbon particles. These carbon-labelled cells showed features either of a monocyte, full-blown macrophages, or typical microglia. It is believed that they are all derived from circulating monocytes which have ingested carbon particles in circulation and thereafter invaded the stab wound.

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