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. 1973 Apr;70(4):1017-21.
doi: 10.1073/pnas.70.4.1017.

A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate

R Sanders, D McGeoch

A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate

R Sanders et al. Proc Natl Acad Sci U S A. 1973 Apr.

Abstract

We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli. Genetic data have indicated that the suppressor of the P(-) mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3':5'-cyclic GMP in addition to their normal effector, 3':5'-cyclic AMP.

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References

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