Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Jan 15;178(1):253-6.
doi: 10.1042/bj1780253.

L-proline transport by newborn rat kidney brush-border membrane vesicles

D R Goldmann, K S Roth, T W Langfitt Jr, S Segal

L-proline transport by newborn rat kidney brush-border membrane vesicles

D R Goldmann et al. Biochem J. .

Abstract

The transport of L-proline was studied in brush-border membrane vesicles isolated from the kidneys of newborn rats. In contrast with the rapid initial uptake with an 'overshoot' observed in adult vesicles, uptake by the newborn vesicle was slow, showed no 'overshoot', and proline continued to accumulate at a time when the adult vesicle had already equilibrated. L-Proline transport in the newborn rat occurs by Na+-dependent and independent mechanisms. There appeared to be essentially no uptake by anti-luminal vesicles isolated from newborn rat kidney. These observations may help to explain the prolinuria that occurs in the newborn animal.

PubMed Disclaimer

References

    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4521-5 - PubMed
    1. Am J Physiol. 1977 Sep;233(3):F241-6 - PubMed
    1. J Biol Chem. 1977 Jan 25;252(2):591-5 - PubMed
    1. J Biol Chem. 1969 Jul 10;244(13):3561-9 - PubMed

Publication types