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. 1973 Jul;70(7):2139-44.
doi: 10.1073/pnas.70.7.2139.

Discrimination between messenger ribonucleic acids by a mammalian translation initiation factor

U Nudel, B Lebleu, M Revel

Discrimination between messenger ribonucleic acids by a mammalian translation initiation factor

U Nudel et al. Proc Natl Acad Sci U S A. 1973 Jul.

Abstract

A factor from rabbit-reticulocyte ribosome, which stimulates by 5-fold initiation of hemoglobin mRNA translation in Krebs ascites cell extracts, was purified to homogeneity. The factor, a protein of about 65,000 molecular weight in sodium dodecyl sulfate, discriminates between various mRNAs: it stimulates translation of alpha globin mRNA and of tobacco mosaic virus RNA, but has only a small effect on beta globin mRNA and no effect at all on Mengo virus RNA translation.

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References

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