Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Sep;52(9):2379-82.
doi: 10.1172/JCI107426.

Cyclic AMP and sodium transport. Quantitative and temporal relationships in toad urinary bladder

V S Sapirstein, W N Scott

Cyclic AMP and sodium transport. Quantitative and temporal relationships in toad urinary bladder

V S Sapirstein et al. J Clin Invest. 1973 Sep.

Abstract

The effects of oxytocin upon tissue cAMP content and short-circuit current (SCC) were measured in the urinary bladder of the toad, Bufo marinus. Tissue cAMP levels doubled before any increment in SCC was observed, the two hormone responses were quantitatively related, and a threshold level for an effect of cAMP upon sodium transport was demonstrated. The period of time over which cAMP levels continued to rise after the threshold level had been attained seemed invariant with hormone concentration. The rate at which cAMP levels rose increased with hormone concentration yielding hormone concentration-dependent maximal levels. The decay of cAMP levels was delayed when sodium influx was curtailed, suggesting a sodium-regulatory effect upon tissue cAMP levels.

PubMed Disclaimer

References

    1. J Biol Chem. 1965 Nov;240(11):4524-6 - PubMed
    1. J Physiol. 1968 Mar;195(2):317-30 - PubMed
    1. Am J Physiol. 1972 Mar;222(3):657-62 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Sep;64(1):367-73 - PubMed
    1. J Biol Chem. 1967 Dec 10;242(23):5535-41 - PubMed