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. 1973 Sep;115(3):982-6.
doi: 10.1128/jb.115.3.982-986.1973.

Cross-feeding of Escherichia coli mutants defective in the biosynthesis of nicotinamide adenine dinucleotide

T J Kerr, G J Tritz

Cross-feeding of Escherichia coli mutants defective in the biosynthesis of nicotinamide adenine dinucleotide

T J Kerr et al. J Bacteriol. 1973 Sep.

Abstract

Mutants of Escherichia coli defective in the biosynthesis of nicotinamide adenine dinucleotide (NAD) are able to grow in a Casamino Acids medium lacking NAD and its immediate precursors, nicotinic acid and nicotinamide. This property has allowed the development of a system to measure cross-feeding between a nadA and a nadB mutant. This system provides a means of isolating the intermediate, prequinolinic acid, as well as a biological assay for the compound. The nadB mutant feeds the nadA mutant, indicating that the nadA enzyme occurs first in the pathway and the nadB enzyme second. No cross-feeding was detected between nadA and nadC or between nadB and nadC.

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References

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