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. 1973 Oct;51(4):1243-54.
doi: 10.1093/jnci/51.4.1243.

A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild mice

M B Gardner, B E Henderson, J E Officer, R W Rongey, J C Parker, C Oliver, J D Estes, R J Huebner

A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild mice

M B Gardner et al. J Natl Cancer Inst. 1973 Oct.

Abstract

A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice (Mus musculus) which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus. The virus appeared to have a direct neurotropic effect on anterior horn neurons in the lower spinal cord.

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