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Comparative Study
. 1974 Feb;13(2):394-9.
doi: 10.1128/JVI.13.2.394-399.1974.

Virus replication in enucleate cells: vesicular stomatitis virus and influenza virus

E A Follett, C R Pringle, W H Wunner, J J Skehel
Comparative Study

Virus replication in enucleate cells: vesicular stomatitis virus and influenza virus

E A Follett et al. J Virol. 1974 Feb.

Abstract

The requirement of the presence of a nucleus for the replication of vesicular stomatitis virus and influenza virus has been examined by following the growth and development of these viruses in enucleate BS-C-1 cells. Vesicular stomatitis virus replicates normally in enucleate cells with the rate of production of infectious virus, the amount of virus-specific protein synthesis, and the type of proteins produced being essentially the same in nucleate and enucleate cells. Influenza virus does not replicate in enucleate cells, no virus gene products can be detected, and there is no inhibition of cellular protein synthesis.

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References

    1. Nature. 1967 Jan 21;213(5073):261-4 - PubMed
    1. Virology. 1970 Apr;40(4):989-96 - PubMed
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