Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Feb 1;139(2):414-26.
doi: 10.1084/jem.139.2.414.

Genetic influences affecting the occurrence of a diabetes mellitus-like disease in mice infected with the encephalomyocarditis virus

J E Craighead, D A Higgins

Genetic influences affecting the occurrence of a diabetes mellitus-like disease in mice infected with the encephalomyocarditis virus

J E Craighead et al. J Exp Med. .

Abstract

The M variant of encephalomyocarditis virus produces a diabetes mellitus-like disease in DBA/2 mice but not in animals of the C3H strain. Fewer than one-third of infected F(1) (DBA/2 x C3H) progeny exhibit the disease, whereas the prevalence in backcrosses (F(1) x DBA/2, F(1) x C3H) is comparable to the parental inbred strain. Thus, the mode of inheritance of the diabetic predisposition appears to be polygenic. DBA/2 animals develop striking inflammatory and necrotizing lesions of the islets of Langerhans; in contrast, alterations of the insular tissue in the C3H mice are minimal. Although metabolic abnormalities appear to be consequent to lesions of beta cells, the factors influencing the severity of these insular changes are incompletely understood.

PubMed Disclaimer

References

    1. Am J Pathol. 1966 Feb;48(2):333-45 - PubMed
    1. Heredity (Edinb). 1962 Feb;17:75-105 - PubMed
    1. J Pathol Bacteriol. 1966 Apr;91(2):467-76 - PubMed
    1. Science. 1968 Nov 22;162(3856):913-4 - PubMed
    1. Diabetes. 1968 Nov;17(11):693-704 - PubMed

MeSH terms