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• Comparison of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma cells grown in vivo and in vitro.

  Beirne OR, Watson JA. Beirne OR, et al. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2735-9. doi: 10.1073/pnas.73.8.2735. Proc Natl Acad Sci U S A. 1976. PMID: 183207 Free PMC article.
• Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo.

  Bilheimer DW, Stone NJ, Grundy SM. Bilheimer DW, et al. J Clin Invest. 1979 Aug;64(2):524-33. doi: 10.1172/JCI109490. J Clin Invest. 1979. PMID: 222811 Free PMC article.
• Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

  Brown MS, Dana SE, Goldstein JL. Brown MS, et al. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2925-9. doi: 10.1073/pnas.72.8.2925. Proc Natl Acad Sci U S A. 1975. PMID: 241998 Free PMC article.
• In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Decreased enzyme catalytic efficiency in familial hypercholesterolemia.

  Stacpoole PW, Bridge DM, Alvarez IM, Goldberg RB, Harwood HJ Jr. Stacpoole PW, et al. J Clin Invest. 1987 Nov;80(5):1401-8. doi: 10.1172/JCI113218. J Clin Invest. 1987. PMID: 2824560 Free PMC article.
• Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.

  Brown MS, Goldstein JL. Brown MS, et al. Proc Natl Acad Sci U S A. 1974 Mar;71(3):788-92. doi: 10.1073/pnas.71.3.788. Proc Natl Acad Sci U S A. 1974. PMID: 4362634 Free PMC article.