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. 1973 Oct;12(4):748-57.
doi: 10.1128/JVI.12.4.748-757.1973.

Reassortment of simian virus 40 DNA during serial undiluted passage

M A Martin, L D Gelb, G C Fareed, J B Milstien

Reassortment of simian virus 40 DNA during serial undiluted passage

M A Martin et al. J Virol. 1973 Oct.

Abstract

Alterations occur in the supercoiled form of viral DNA after the serial undiluted passaging of simian virus (SV) 40. We have identified a portion of the viral genome which is amplified during this process. These SV40 DNA sequences represent about 30% of the viral genetic information and are present in a reiterated form in twisted circular molecules prepared from purified virions. In addition, reiterated and unique green monkey DNA sequences are incorporated into supercoiled viral DNA. The cellular DNA appears to be inserted at numerous locations in the DNA I molecules.

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References

    1. Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1967 May;57(5):1514-21 - PubMed
    1. Virology. 1968 Mar;34(3):391-401 - PubMed
    1. Virology. 1968 Mar;34(3):402-9 - PubMed
    1. Science. 1968 Aug 9;161(3841):529-40 - PubMed

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