doi: 10.1073/pnas.71.2.298.
Absence of a specific ganglioside galactosyltransferase in mouse cells transformed by murine sarcoma virus
- PMID: 4360937
- PMCID: PMC387990
- DOI: 10.1073/pnas.71.2.298
Item in Clipboard
Absence of a specific ganglioside galactosyltransferase in mouse cells transformed by murine sarcoma virus
Proc Natl Acad Sci U S A.
1974 Feb.
Abstract
The ganglioside composition of a nonproducer subclone (derived from BALB/c 3T3 mouseembryo cells) transformed by Kirsten murine sarcoma virus was drastically altered compared to the nontransformed parental clone. The transformed clone was unable to synthesize the mono- and disialogangliosides, G(M1) and G(D1a), due to the complete absence of a specific galactosyltransferase. The lack of this enzyme activity was established by sensitive radiochemical and enzymological techniques in vivo and in vitro.
Similar articles
-
A comparison of membrane glycoconjugates from mouse cells transformed by murine and primate RNA sarcoma viruses.Biochemistry. 1976 Jan 13;15(1):201-8. doi: 10.1021/bi00646a031. Biochemistry. 1976. PMID: 174712
-
Altered ganglioside biosynthesis in mouse cell cultures following transformation with chemical carcinogens and x-irradiation.J Biol Chem. 1975 Jan 10;250(1):55-60. J Biol Chem. 1975. PMID: 237893
-
Transformation of Swiss 3T3 cells by murine sarcoma virus is followed by decrease in a glycolipid glycosyltransferase.Nat New Biol. 1973 Oct 24;245(147):226-9. doi: 10.1038/newbio245226a0. Nat New Biol. 1973. PMID: 4518362 No abstract available.
-
Biosynthesis of glycolipids in virus-transformed cells.Biochim Biophys Acta. 1974 Sep 9;355(2):121-48. doi: 10.1016/0304-419x(74)90001-8. Biochim Biophys Acta. 1974. PMID: 4369815 Review. No abstract available.
-
Composition of membranes of cells transformed by tumorigenic DNA and RNA viruses.Am J Clin Pathol. 1975 May;63(5):685-94. doi: 10.1093/ajcp/63.5.685. Am J Clin Pathol. 1975. PMID: 165709 Review.
Cited by
-
The requirements for viral entry differ from those for virally induced syncytium formation in NIH 3T3/DTras cells exposed to Moloney murine leukemia virus.J Virol. 1992 Dec;66(12):7262-9. doi: 10.1128/JVI.66.12.7262-7269.1992. J Virol. 1992. PMID: 1433518 Free PMC article.
-
Neutral glycolipids and gangliosides of concanavalin A-selected SV3T3 revertant cells and of normal and SV40-transformed Balb/c 3T3 cells.Biochem J. 1981 Mar 1;193(3):1025-8. doi: 10.1042/bj1931025. Biochem J. 1981. PMID: 6272715 Free PMC article.
-
Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors.Proc Natl Acad Sci U S A. 1976 Mar;73(3):842-6. doi: 10.1073/pnas.73.3.842. Proc Natl Acad Sci U S A. 1976. PMID: 176657 Free PMC article.
-
Gangliosides sensitize unresponsive fibroblasts to Escherichia coli heat-labile enterotoxin.J Clin Invest. 1979 Aug;64(2):381-4. doi: 10.1172/JCI109472. J Clin Invest. 1979. PMID: 222809 Free PMC article.
-
Cell surface glycolipids of transformed NIH 3T3 cells transfected with DNAs of human bladder and lung carcinomas.EMBO J. 1983;2(12):2323-6. doi: 10.1002/j.1460-2075.1983.tb01741.x. EMBO J. 1983. PMID: 6667678 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
