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. 1974 Apr 12;184(4133):158-60.
doi: 10.1126/science.184.4133.158.

Dexamethasone stimulation of murine mammary tumor virus expression: a tissue culture source of virus

W P Parks, E M Scolnick, E H Kozikowski

Dexamethasone stimulation of murine mammary tumor virus expression: a tissue culture source of virus

W P Parks et al. Science. .

Abstract

In mouse cell lines derived from mammary adenocarcinomnas, the synthetic steroid dexamnethasone stimulates production of murine mammary tumor virus. Viral RNA and antigens are increased as much as 20-fold, and culture fluid supernatants from steroid-treated cells contain type B particles with reverse transcriptase. These cells provide a possible tissue culture source of this virus and a model system for studying the mechanism of action of corticosteroids and the regulation of transcription of integrated viral DNA.

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