Abstract

PIP: Presented is a report of 737 women subjected to hysterectomy and subsequently given estrogen therapy with conjugated equine estrogens. A total of 9899 patient-years were studied. The original objective of the study was to evaluate the role of estrogen in the development of carcinoma of the breast. No statistical increase in breast cancer was observed. The most striking finding was the unexpectedly low incidence of all cancer and the markedly low mortality rate. A study was carried out on the subjective response of 550 of the women. Questions were asked on general health, emotional status, and sex. 477 of the women said their health was better, 338 said that their nerves were better, and 181 out of 373 (61 were unmarried) said that sex was better. It believed that due to the use of estrogen, delays were effected in the onset of osteoporosis, and these resulted in an improvement of the incidence of the skeletal fractures which might be anticipated in this age group.