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. 1973 Nov;70(11):3067-71.
doi: 10.1073/pnas.70.11.3067.

Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts

H E Varmus, P K Vogt, J M Bishop

Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts

H E Varmus et al. Proc Natl Acad Sci U S A. 1973 Nov.

Abstract

A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated.

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References

    1. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1288-95 - PubMed
    1. Virology. 1970 Jan;40(1):118-34 - PubMed
    1. J Mol Biol. 1971 Apr 14;57(1):129-45 - PubMed
    1. Nat New Biol. 1971 Sep 1;233(35):19-21 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1844-7 - PubMed

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