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. 1974 Mar;71(3):694-8.
doi: 10.1073/pnas.71.3.694.

Intracellular cyclic AMP concentration responds specifically to growth regulation by serum

J Oey, A Vogel, R Pollack

Intracellular cyclic AMP concentration responds specifically to growth regulation by serum

J Oey et al. Proc Natl Acad Sci U S A. 1974 Mar.

Abstract

Intracellular concentrations of cyclic AMP increase when cells are deprived of serum. Studies with the mouse fibroblast line 3T3, an SV40-transformed subline of 3T3, and six different revertant lines derived from this clone show that a marked increase in cyclic AMP occurs only when the serum concentration is reduced below the minimum necessary for growth of a given line. Conversely, density-dependent inhibition of growth is not accompanied by an increase in cyclic AMP concentration in any line.

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References

    1. Virology. 1964 May;23(1):117-9 - PubMed
    1. J Cell Physiol. 1965 Dec;66(3):325-33 - PubMed
    1. Wistar Inst Symp Monogr. 1967;7:87-101 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 May;60(1):126-33 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 May;60(1):300-4 - PubMed

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