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. 1974 Feb;138(2):195-9.
doi: 10.1042/bj1380195.

A protein kinase inhibitor in brown adipose tissue of developing rats

J P Skala, G I Drummond, P Hahn

A protein kinase inhibitor in brown adipose tissue of developing rats

J P Skala et al. Biochem J. 1974 Feb.

Abstract

A heat-stable protein was extracted from brown adipose tissue of infant rats that inhibited both purified bovine heart protein kinase and a crude preparation of protein kinase from brown fat. It did not act as an adenosine triphosphatase nor did it exert its effect by proteolytic action. Inhibition of protein kinase was affected in both the presence and the absence of cyclic AMP. Most of the inhibitory activity was present in the 100000g supernatant fraction of tissue homogenates. Inhibitory activity was highest perinatally and it declined 10 days after birth. It is suggested that the protein kinase inhibitor may play a role in regulating cyclic AMP actions.

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References

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