Effects of collagen and of aspirin on the concentration of guanosine 3':5'-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique
- PMID: 4362746
- PMCID: PMC1166211
- DOI: 10.1042/bj1380317
Effects of collagen and of aspirin on the concentration of guanosine 3':5'-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique
Abstract
A method is described for isolating cyclic [(3)H]GMP from platelets preincubated with [(3)H]guanine. Collagen increased and aspirin decreased the cyclic [(3)H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.
Similar articles
-
Elevation of the cyclic GMP concentration in human platelets by sodium ascorbate and 5-hydroxytryptamine.J Cyclic Nucleotide Res. 1977 Oct;3(5):355-65. J Cyclic Nucleotide Res. 1977. PMID: 201683
-
The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation.J Cyclic Nucleotide Res. 1977 Feb;3(1):37-44. J Cyclic Nucleotide Res. 1977. PMID: 191476
-
Role of cyclic nucleotides in rapid platelet adhesion to collagen.Blood. 1994 May 1;83(9):2508-15. Blood. 1994. PMID: 7513202
-
Role of cyclic AMP in platelet function.Adv Cyclic Nucleotide Res. 1972;1:231-47. Adv Cyclic Nucleotide Res. 1972. PMID: 4353170 Review. No abstract available.
-
[Biochemical mechanism of blood platelet release reaction, aggregation and adhesiveness].Nihon Rinsho. 1978 Dec 10;36(12):3798-804. Nihon Rinsho. 1978. PMID: 219272 Review. Japanese. No abstract available.
Cited by
-
Platelets, thrombosis and drugs.Drugs. 1975;9(1):19-76. doi: 10.2165/00003495-197509010-00003. Drugs. 1975. PMID: 1092540 Review.
-
Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation.Blood. 2011 Sep 29;118(13):3670-9. doi: 10.1182/blood-2011-03-341107. Epub 2011 Jul 29. Blood. 2011. PMID: 21803853 Free PMC article.
-
Substances that increase the cyclic AMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid.Agents Actions. 1975 May;5(2):137-44. doi: 10.1007/BF02027355. Agents Actions. 1975. PMID: 51579
-
The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function.Cells. 2022 Nov 21;11(22):3704. doi: 10.3390/cells11223704. Cells. 2022. PMID: 36429131 Free PMC article. Review.
-
Violet LED induces vasodilation in rat aortic rings by soluble guanylate cyclase-dependent mechanism and increases SOD activity.Lasers Med Sci. 2022 Feb;37(1):537-544. doi: 10.1007/s10103-021-03293-2. Epub 2021 Mar 18. Lasers Med Sci. 2022. PMID: 33735421
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources