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. 1979 Feb;35(2):163-70.

Abnormal lymphocyte responses in residents of a town with a cluster of Hodgkin's disease

J F Plouffe, J Silva, R S Schwartz, J P Callen, P Kane, L A Murphy, I J Goldstein, R Fekety

Abnormal lymphocyte responses in residents of a town with a cluster of Hodgkin's disease

J F Plouffe et al. Clin Exp Immunol. 1979 Feb.

Abstract

A time-space aggregate of Hodgkin's disease was observed in a small town. A large elevator for the storage of navy beans was located in the residential area of the town. Lymphocytes of town residents compared to those of non-residents showed increased levels of transformations when challenged with extracts of navy beans. A phytohaemagglutinin from navy beans with the ability to stimulate lymphocytes was isolated and characterized. A hypothesis concerning a connection between this cluster of Hodgkin's disease and the abnormal lymphocyte responses to navy-bean phytohaemagglutinin is discussed.

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