doi: 10.1084/jem.139.5.1350.
Concordant segregation of the expression of SV40 T antigen and human chromosome 7 in mouse-human hybrid subclones
- PMID: 4363410
- PMCID: PMC2139669
- DOI: 10.1084/jem.139.5.1350
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Concordant segregation of the expression of SV40 T antigen and human chromosome 7 in mouse-human hybrid subclones
J Exp Med.
.
Abstract
Subcloning of Simian virus 40 (SV40) T antigen-positive mouse-human hybrids, derived from the fusion of mouse cells deficient in thymidine kinase with SV40-transformed Lesch Nyhan fibroblasts, resulted in their segregation into T antigen-positive and negative subclones. Positive correlation between the presence of human chromosome 7 and the expression of SV40 T antigen was established in the subclones examined. These results negate the possibility of a transfer of the SV40 genome to a mouse chromosome.
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