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. 1974 Jun 14;184(4142):1185-7.
doi: 10.1126/science.184.4142.1185.

Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy

M A Walz, R W Price, A L Notkins

Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy

M A Walz et al. Science. .

Abstract

Inoculation of the cornea, lip, or footpad of mice with herpes simplex virus type 1 resulted in a latent infection of the local sensory ganglia. Inoculation of the vagina and cervix with herpes simplex virus type 2, as well as type 1, also induced a latent ganglionic infection. With the use of sciatic nerve section as a stimulus, a reproducible model of viral reactivation in vivo was established.

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