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. 1974 Jun 14;184(4142):1188-91.
doi: 10.1126/science.184.4142.1188.

Thyroid hormone action: in vitro demonstration of putative receptors in isolated nuclei and soluble nuclear extracts

H H Samuels, J S Tsai, J Casanova

Thyroid hormone action: in vitro demonstration of putative receptors in isolated nuclei and soluble nuclear extracts

H H Samuels et al. Science. .

Abstract

Saturable binding activities for triiodothyronine were demonstrated in vitro with isolated nuclei and soluble nuclear extracts of rat liver, kidney, and cultured GH(1) cells. The binding activity can be extracted from nuclei in soluble form with no significant change in hormone affinity and has properties of a nonhistone protein.

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