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. 1974 Apr;71(4):1418-21.
doi: 10.1073/pnas.71.4.1418.

The three-state model: a minimal allosteric description of homotropic and heterotropic effects in the binding of ligands to hemoglobin

A P Minton, K Imai

The three-state model: a minimal allosteric description of homotropic and heterotropic effects in the binding of ligands to hemoglobin

A P Minton et al. Proc Natl Acad Sci U S A. 1974 Apr.

Abstract

The effect of hydrogen ion, chloride, and 2,3-diphosphoglycerate upon the oxygen binding of hemoglobin may be satisfactorily described by an allosteric model employing three affinity states. The allosteric two-state model does not provide even an approximate description except under defined extreme conditions. In particular, the two-state model cannot provide a correct interpretation of recently reported electron spin resonance and nuclear magnetic resonance data.

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References

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