doi: 10.1073/pnas.71.4.1534.
A molecular model of high density lipoproteins
- PMID: 4364543
- PMCID: PMC388265
- DOI: 10.1073/pnas.71.4.1534
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A molecular model of high density lipoproteins
Proc Natl Acad Sci U S A.
1974 Apr.
Abstract
Based on the analysis of recombined lipidapoprotein complexes by C-13 and P-31 nuclear magnetic resonance spectroscopy and circular dichroism [Assmann, G., Sokoloski, E. A. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, 549-553; Assmann, G., Highet, R. J., Sokoloski, E. A. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, in press; Assmann, G. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, 989-993] and the identification of conformational amphipathic regions in apoproteins, a new model for human high density lipoproteins is proposed. This model is analogous to membrane models proposed by Singer, in that protein "icebergs" are embedded in a "sea" of lipid.
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