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. 1974 May;71(5):1887-90.
doi: 10.1073/pnas.71.5.1887.

Visualization of single-stranded nucleic acid of RNA tumor virus with the electron microscope

G H Weber, U Heine, M Cottler-Fox, G S Beaudreau

Visualization of single-stranded nucleic acid of RNA tumor virus with the electron microscope

G H Weber et al. Proc Natl Acad Sci U S A. 1974 May.

Abstract

60-70S RNA of avian myeloblastosis virus was spread with the Kleinschmidt method and examined in the electron microscope after being subjected to a variety of denaturing conditions. Extension of the molecules from a collapsed configuration was seen only under stringent denaturing conditions, resulting in molecules of 1-2 mum in length. Longer strands of these extremely fragile molecules cannot be obtained with the methods presently available.

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References

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