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. 1974 May;71(5):2003-7.
doi: 10.1073/pnas.71.5.2003.

An RNA-dependent nucleoside triphosphate phosphohydrolase (ATPase) associated with rho termination factor

C Lowery-Goldhammer, J P Richardson

An RNA-dependent nucleoside triphosphate phosphohydrolase (ATPase) associated with rho termination factor

C Lowery-Goldhammer et al. Proc Natl Acad Sci U S A. 1974 May.

Abstract

Highly purified rho termination factor from Escherichia coli catalyzes an RNA-dependent hydrolysis of ribonucleoside triphosphates to nucleoside diphosphates and inorganic phosphate. In the presence of poly(C), a specific activity of 100 mumole of ATP hydrolyzed per min/mg has been measured. The phosphohydrolase activity appears to be associated with the protein responsible for termination of RNA synthesis, but a functional relationship between the two activities is not yet evident. Hydrolysis of nucleoside triphosphates occurs in the absence of termination and without any extensive degradation of RNA.

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