doi: 10.1126/science.185.4151.612.
Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus)
- PMID: 4366489
- DOI: 10.1126/science.185.4151.612
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Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus)
Science.
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Abstract
Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.
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