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. 1974 Aug 16;185(4151):612-4.
doi: 10.1126/science.185.4151.612.

Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus)

A W Wood, A H Conney

Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus)

A W Wood et al. Science. .

Abstract

Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.

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