[Arterial scleroproteins in atherosclerosis and hypertension (experimental studies)]

Abstract

The authors examined neosynthesis of fiber proteins (scleroproteins) in the aorta of rats with genetic hypertonia and with experimental atherosclerosis after application of 3H-proline and 3H-lysine and subsequent determination of radioactivity of collagenous and elastic in the aortic wall. There was a great increase in incorporation a labelled precursors of collagen and elastin in the aorta of hypertonic and atherosclerotic animals in comparison with the control rats-a manifestation of increased "de novo" synthesis of fiber proteins in rats with these arterial diseases. Furthermore the increased collagenosis dominated over that of elastogenesis. The irregularity in the activation of biosynthesis of both sclero-proteins in rats with hypertonia and atherosclerosis caused remodeling of macromolecular structure of the aretrial wall with a predominance of collagen over the remaining components of the connective tissue matrix. The resulting fibrosis of the arterial wall favoured the fixation of hypertonia and progression of atherosclerosis.