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. 1974 Jul;29(4):432-6.
doi: 10.1136/thx.29.4.432.

A critical investigation into the antibiotic sterilization of heart valve homografts

P M Waterworth, E Lockey, E M Berry, H M Pearce

A critical investigation into the antibiotic sterilization of heart valve homografts

P M Waterworth et al. Thorax. 1974 Jul.

Abstract

Waterworth, Pamela M., Lockey, Eunice, Berry, E. M., and Pearce, Helen M. (1974).Thorax, 29, 432-436. A critical investigation into the antibiotic sterilization of heart valve homografts. Sterility tests of homograft heart valves sterilized by antibiotics were found to be invalidated by carry-over of the antibiotics. A method was devised to test the efficacy of different antibiotic mixtures using membrane filters. Fifty-five organisms, including 13 species, were tested, and sterility was achieved with only 35.

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