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. 1974 Jul;71(7):2803-7.
doi: 10.1073/pnas.71.7.2803.

Interaction of phalloidin with actin

A M Lengsfeld, I Löw, T Wieland, P Dancker, W Hasselbach

Interaction of phalloidin with actin

A M Lengsfeld et al. Proc Natl Acad Sci U S A. 1974 Jul.

Abstract

Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionic strength. Ph-actin closely resembles the microfilaments found in liver membrane fractions (Ph-filaments) after in vivo or in vitro poisoning. Both phalloidin induced filaments are resistant to 0.6 M KI in contrast to F-actin, and become decorated by heavy meromyosin. After preincubation with cytochalasin B significantly fewer actin filaments are observed.

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