Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Apr 15;35(4):521-2.
doi: 10.1007/BF01922745.

Transdermal uptake of a peptide hormone: inhibition by calcitonin eardrops of induced osteolysis in guinea-pig ossicles

C G Rudman, J A Parsons

Transdermal uptake of a peptide hormone: inhibition by calcitonin eardrops of induced osteolysis in guinea-pig ossicles

C G Rudman et al. Experientia. .

Abstract

In view of a recent proposal that calcitonin injections may arrest the bony pathology of otosclerosis, we have tested the possibility of obtaining locally effective concentrations by giving salmon calcitonin in eardrops. Osteolysis of guinea-pig ossicles induced by injecting parathyroid hormone shortly before explantation was markedly inhibited by 3 days prior instillation of the calcitonin in an aqueous vehicle or in dimethyl sulphoxide, but not by a solution in propylene carbonate.

PubMed Disclaimer

References

    1. Br Med J. 1973 Mar 24;1(5855):744-5 - PubMed
    1. Vitam Horm. 1971;29:41-93 - PubMed
    1. N Engl J Med. 1970 Apr 16;282(16):909-16 - PubMed
    1. Br Med J. 1977 Aug 20;2(6085):485-7 - PubMed
    1. Br Med J. 1974 Oct 26;4(5938):203 - PubMed

MeSH terms