Abstract

PIP: To find a suitable contraceptive combination 11 dosage combinations of estrogen and megestrol acetate were studied clinically. An additional combination for treatment of menopausal symptoms was used in 603 treatments, each with 21 pills. A dose of 3.75 mg and even 4.0 mg of conjugated estrogen was not sufficient to inhibit ovulation. Pregnancies occurred also when 21 daily doses of 3 mg conjugated estrogen were combined with 2 or 3 mg megestrol acetate daily. Consequently, not even 3 mg megestrol acetate can be considered a sufficient dose to prevent the pentration of spermatozoa through the cervical mucus when used in combination with estrogens. Clinically best results were obtained with following 2 combinations (2 and 7): conjugated estrogen 3.75 mg/day for 21 days + 5 mg megestrol acetate for the last 5 days and conjugated estrogen 4 mg/day for 21 days + 5 mg megestrol acetate for the last 7 days. The tolerance to conjugated estrogen was good in the whole series. No embolism was observed, nor were any changes in the ASAT; GOT or ALAT; GPT values recorded.