[Effect of heparin complexed with urea on tumor growth and the ultrastructure of malignant cells]

Abstract

Sarcoma 45 cells were inoculated subcutaneously to rats and carcinosarcoma. Walker 256 cells implanted intramuscularly in the Wistar rats. The injections of the heparin-urea complex with a simultaneous blocking of the vegetative nerves system created an anticoagulant and fibrinolytic background in the organism of these animals and produced an antitumorigenic effect, i.e. the inhibition of growth of primary tumors and metastases, the mitotic activity decline in the malignant tissue and a change in the submicroscopic structure of the sarcoma 45 cells (greater chromatin density, prevalence of the fibrillar component in the nuclei, swelling of the reticulum channels, condensation of mitochondria and reduction of polysomes). All this shows the physiological activity of malignant cells to decline through imitating the hyperfunction of the anticoagulation blood system.