Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Oct 4;186(4158):61-3.
doi: 10.1126/science.186.4158.61.

Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state

Y H Tan, E L Schneider, J Tischfield, C J Epstein, F H Ruddle

Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state

Y H Tan et al. Science. .

Abstract

Human primary skin fibroblasts trisomic for chromosome 13, 18, or 21 and diploid human skin fibroblasts were induced for an antiviral response with human interferon. The cells that were trisomnic for chromosome 21 were three to seven times more sensitive to protection by human interferon than the normal diploid or trisomic 18 or 13 fibroblasts. The differential response in trisomnic 21 cells is consistent with the known assignment of the human antiviral gene to chromosome 21.

PubMed Disclaimer

MeSH terms

LinkOut - more resources