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. 1974 Oct;71(10):4077-81.
doi: 10.1073/pnas.71.10.4077.

Initiation of oncogenic transformation of mouse lymphocytes in vitro by Abelson leukemia virus

M D Sklar, B J White, W P Rowe

Initiation of oncogenic transformation of mouse lymphocytes in vitro by Abelson leukemia virus

M D Sklar et al. Proc Natl Acad Sci U S A. 1974 Oct.

Abstract

While C-type RNA viruses are known to induce leukemias and lymphomas, oncogenic transformation of lymphoid cells by them in vitro has not been reported. In this study, splenocytes from female BALB/c mice were infected in vitro with Abelson virus, a C-type RNA virus that induces nonthymic lymphomas and plasmacytomas in mice. The cells were transplanted into recipients of different karyotype, either male BALB/c mice or hybrid BALB/c x AL/N (CALF1) mice, which bear the Rb(5.19)1Wh translocation. Transplants of eight of the resulting tumors (one plasmacytoma and seven lymphomas) contained cells of donor BALB/c karyotype, indicating that transformation of splenocytes occurred in vitro.

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