Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Sep;71(9):3560-4.
doi: 10.1073/pnas.71.9.3560.

The nucleotide sequence complexity of avian tumor virus RNA

M A Billeter, J T Parsons, J M Coffin

The nucleotide sequence complexity of avian tumor virus RNA

M A Billeter et al. Proc Natl Acad Sci U S A. 1974 Sep.

Abstract

The nucleotide sequence complexity of 60-70S RNA of Rous sarcoma virus was determined from the molar yields of 11 pure oligonucleotides of known chain length, obtained from [(32)P]RNA of Rous sarcoma virus by T1 RNase digestion and two-dimensional polyacrylamide gel electrophoresis. We calculate an apparent chain length of about 9800 nucleotides, corresponding to a molecular weight of 3.4 x 10(6). Assuming the molecular weight of 60-70S RNA of Rous sarcoma virus to be about 10(7), our data suggest that the virus genome consists of identical, or very similar, nucleotide sequences repeated three to four times.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1965 Jul;54(1):137-44 - PubMed
    1. Biochemistry. 1968 Feb;7(2):865-74 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1511-8 - PubMed
    1. J Gen Virol. 1969 Apr;4(3):449-52 - PubMed
    1. Nature. 1969 Sep 6;223(5210):1009-14 - PubMed

LinkOut - more resources