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. 1974 Sep;141(3):715-9.
doi: 10.1042/bj1410715.

Phosphonomethyl analogues of phosphate ester glycolytic intermediates

H B Dixon, M J Sparkes

Phosphonomethyl analogues of phosphate ester glycolytic intermediates

H B Dixon et al. Biochem J. 1974 Sep.

Abstract

Analogues of dihydroxyacetone phosphate and of 3-phosphoglycerate were made in which the phosphate group, -O-PO(3)H(2), is replaced by the phosphonomethyl group, -CH(2)-PO(3)H(2). The analogue of dihydroxyacetone phosphate is a substrate for aldolase and glycerol 1-phosphate dehydrogenase (Stribling, 1974), but not for triose phosphate isomerase. The analogue of 3-phosphoglycerate oxidizes NADH under the combined action of 3-phosphoglycerate kinase and glyceraldehyde 3-phosphate dehydrogenase if ATP is added. Thus four out of the five glycolytic enzymes tested handle the phosphonomethyl compounds like the natural phosphates.

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