Circadian rhythms of liver enzymes and their relationship to enzyme induction

Abstract

Tyrosine alpha ketoglutarate transaminase, which is rapidly induced by various agents, shows circadian rhythmicity in the intact rat. This rhythmicity is only slightly altered after adrenalectomy, indicating that adrenal hormones do not play a major role in the metabolic control of the activity of tyrosine alpha ketoglutarate transaminase. On the other hand, phenylalaninepyruvate transaminase, which is not inducible over the same time period, does not show circadian variation. The results suggest that the sensitivity of an enzyme's regulating system to inducing agents may be related to the inherent circadian rhythm of the enzyme.