Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Apr;189(3):393-402.
doi: 10.1113/jphysiol.1967.sp008175.

The action of dopamine on neurones of the caudate nucleus

H McLennan, D H York

The action of dopamine on neurones of the caudate nucleus

H McLennan et al. J Physiol. 1967 Apr.

Abstract

1. Dopamine applied iontophoretically to neurones of the caudate nucleus of cats caused excitation of some (9% of those encountered) and depression of others (60%). Some cells have been found affected both by dopamine and by acetylcholine.2. The effects of dopamine could be prevented by the previous iontophoretic administration of phenoxybenzamine, but not by dichloroisopropylnoradrenaline.3. Responses evoked in caudate neurones by electrical stimulation of substantia nigra were depressed by dopamine. No evidence for enhancement of the effects of nigral stimulation through the application of dopamine were detected.4. Stimulation of nucleus centromedianus thalami depressed firing of caudate neurones.5. The hypothesis that dopamine may act as an inhibitory synaptic transmitter within the caudate is put forward.

PubMed Disclaimer

References

    1. Brain. 1966 Mar;89(1):37-52 - PubMed
    1. J Physiol. 1966 Jul;185(2):298-322 - PubMed
    1. J Physiol. 1966 May;184(1):78-105 - PubMed
    1. Brain. 1965 Mar;88:181-92 - PubMed
    1. Acta Pharmacol Toxicol (Copenh). 1964;21:283-9 - PubMed

LinkOut - more resources