doi: 10.1093/infdis/139.2.235.
Unmasking of actual and potential receptor sites for cholera toxin in intestinal mucosal homogenates
- PMID: 438537
- DOI: 10.1093/infdis/139.2.235
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Unmasking of actual and potential receptor sites for cholera toxin in intestinal mucosal homogenates
J Infect Dis.
1979 Feb.
Abstract
Endongenous and exogenous sialidases appear to unmask sialidase-stable and sialidase-labile gangliosides in intestinal mucosal homogenates by attacking glycoproteins. Exogenous (but not endogenous) sialidase then converts sialidase-labile gangliosides into the cholera toxin-binding, sialidase-stable ganglioside GM1 (galactosyl-N-acetylgalactosaminyl [sialosyl] lactosyl ceramide). Since Vibrio cholerae produces sialidase, these observations may be relevant to the course of cholera.
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