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. 1968 Nov 22;162(3856):917-8.
doi: 10.1126/science.162.3856.917.

Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding

C S Lieber, L M DeCarli

Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding

C S Lieber et al. Science. .

Abstract

Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.

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