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. 1969 Mar;62(3):741-8.
doi: 10.1073/pnas.62.3.741.

Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat

M J Besson, A Cheramy, P Feltz, J Glowinski

Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat

M J Besson et al. Proc Natl Acad Sci U S A. 1969 Mar.

Abstract

The extraneuronal spontaneous efflux of (3)H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the (3)H amine in superfusates of isolated striatum of the rat previously incubated with (3)H-tyrosine. The (3)H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of (3)H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.

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References

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