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. 1969 Mar;62(3):756-63.
doi: 10.1073/pnas.62.3.756.

D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system

M J Cline, R I Lehrer

D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system

M J Cline et al. Proc Natl Acad Sci U S A. 1969 Mar.

Abstract

D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase constitute a biochemically specific system for the recognition and killing of certain microorganisms.

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References

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