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. 1970 Dec;67(4):1914-7.
doi: 10.1073/pnas.67.4.1914.

Leukemia virus activation in chronic allogeneic disease

M S Hirsch, P H Black, G S Tracy, S Leibowitz, R S Schwartz

Leukemia virus activation in chronic allogeneic disease

M S Hirsch et al. Proc Natl Acad Sci U S A. 1970 Dec.

Abstract

Young adult (BALB/c x A/J)F(1) hybrid mice have no detectable leukemia viruses. When inoculated with parental BALB/c spleen lymphoid cells, also free of detectable virus, leukemia viruses rapidly become activated in the injected host. Because of similarities between such graft-induced allogeneic disease and spontaneous autoimmunity, it is proposed that autoimmune reactions may activate latent viruses.

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