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. 1971 Jun 4;172(3987):1034-6.
doi: 10.1126/science.172.3987.1034.

Calcium: is it required for transmitter secretion?

D M Quastel, J T Hackett, J D Cooke

Calcium: is it required for transmitter secretion?

D M Quastel et al. Science. .

Abstract

Ethanol multiplies miniature end-plate potential frequency independently of calcium ion concentrations and also multiplies calcium-dependent depolarization-evoked quantal release, to the same extent. This result implies a final common pathway, requiring little or no calcium, for both kinds of transmitter secretion. Chlorpromazine and hypertonicity act similarly to ethanol, but also depress depolarization-secretion coupling.

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