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. 1971 Nov;125(2):385-93.
doi: 10.1042/bj1250385.

Metabolism of m-tert.-butylphenyl N-methylcarbamate in insects and mice

P G Douch, J N Smith

Metabolism of m-tert.-butylphenyl N-methylcarbamate in insects and mice

P G Douch et al. Biochem J. 1971 Nov.

Abstract

The metabolism of m-tert.-butylphenyl N-methylcarbamate was studied in mice and five species of insects. Both the tert.-butyl group and the N-methyl group were hydroxylated. The major phenolic metabolite was m-(beta-hydroxy-tert.-butyl)phenol, which was identified by mass spectroscopy. Significant amounts of dihydroxy compounds were formed at a constant rate from the start of the enzymic oxidation process. The considerable species variation in the yields of the different types of oxidation products suggests that N-demethylation and oxidation of the tert.-butyl groups were catalysed by different enzymes. A microsomal NADPH-dependent enzyme also catalysed the splitting of the ester link in the insecticide.

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