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Review
. 1971:7:112-45.
doi: 10.1111/j.1600-065x.1971.tb00465.x.

Iatrogenic alterations of immunologic surveillance in man and their influence on malignancy

T E Starzl, I Penn, C W Putnam, C G Groth, C G Halgrimson
Review

Iatrogenic alterations of immunologic surveillance in man and their influence on malignancy

T E Starzl et al. Transplant Rev. 1971.
No abstract available

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Figures

Figure 1
Figure 1
Disseminated reticulum cell sarcoma in a renal homograft recipient in our series (Table I, Case 14). A: This 5 cm nodule was one of several found in the liver. B: Malignant reticulum cells have massively infiltrated the thyroid, separating the follicles widely (× 80). (By permission of Transplant. Proc. 1, 106, 1969.)
Figure 2
Figure 2
Case 15 in Colorado series (see Table I). Tumor nodules (arrows) in the left occipital lobe and cerebellum. The flattened gyri reflect increased intracranial pressure caused by the tumor. Insert – the large uniform cells with indistinct cytoplasm and round to oval nuclei are characteristic of reticulum cell sarcoma (× 350). (By permission of Transplant. Proc. 1, 106, 1969.)
Figure 3
Figure 3
Pneumoencephalogram in a 20-year-old woman who had been treated with renal homotransplantation a few months previously. Progressive hemiparesis had developed postoperatively. A mass was found, protruding into the right lateral ventricle. This was biopsied with stereotaxic apparatus and found to be a plasmacytoma. (By permission of Radiology 95, 1, 1970.)
Figure 4
Figure 4
The clinical course of the patient whose pneumoencephalogram is shown in Figure 3. When the diencephalic tumor was diagnosed, immunosuppression was drastically reduced, and the intracranial neoplasm was irradiated with a total of 5,650 R. Kidney function was well maintained, and tumor growth is apparently arrested since the patient has been well for more than three subsequent years. (By permission of Transplant. Proc. 1, 106, 1969.)
Figure 5
Figure 5
A small hepatoma (surrounded by arrows) in a liver that was replaced at the age of 3 years, 10 months, because of biliary atresia.
Figure 6
Figure 6
Destruction of an orthotopic liver homograft by tumor recurrence. The posteroanterior and lateral liver scans were obtained with technetium. A: 68 days. The scan is normal. B: 94 days. The patient had become jaundiced. Hepatomegaly is evident. C: 101 days. Multiple areas of poor isotope concentration are now visible. D: 111 days. The process has continued its rapid progression. By the time of death one month later, the homograft was almost completely replaced with carcinoma. (By permission of W. B. Saunders Co., 1969.)
Figure 6
Figure 6
Destruction of an orthotopic liver homograft by tumor recurrence. The posteroanterior and lateral liver scans were obtained with technetium. A: 68 days. The scan is normal. B: 94 days. The patient had become jaundiced. Hepatomegaly is evident. C: 101 days. Multiple areas of poor isotope concentration are now visible. D: 111 days. The process has continued its rapid progression. By the time of death one month later, the homograft was almost completely replaced with carcinoma. (By permission of W. B. Saunders Co., 1969.)
Figure 7
Figure 7
Experimental procedure in patients with disseminated malignancies who were treated with splenic homotransplantation. Note that the donor is sensitized with the recipient’s tumor in each case. (By permission of Sth. med. J. 58, 131, 1965.)
Figure 8
Figure 8
Photomicrograph of splenic homograft obtained at autopsy 2 operatively. Note the widespread necrosis with complete loss of architecture (hematoxylin and eosin, × 80). (By permission of Ann. N.Y. Acad. Sci. 120, 626, 1964.)
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References

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