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. 1972 Oct;46(2):348-50.
doi: 10.1111/j.1476-5381.1972.tb06880.x.

Characterization of the coronary vascular -adrenoceptor in the pig

G M Drew, G P Levy

Characterization of the coronary vascular -adrenoceptor in the pig

G M Drew et al. Br J Pharmacol. 1972 Oct.

Abstract

The beta-adrenoceptor in pig coronary vascular smooth muscle has been characterized by the use of a selective agonist, salbutamol and a selective antagonist, practolol. In coronary artery strips contracted with KCI, salbutamol had only marginal relaxant activity and was a partial agonist compared with isoprenaline. Practolol had relatively high antagonist potency against isoprenaline (pA(2) 6.59). It is concluded that the pig coronary vascular,beta-adrenoceptor is of the beta(1)-type.

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References

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